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Saliva is a reliable and practical source of germline DNA for genome-wide studies in chronic lymphocytic leukemia.

Leukemia research - 1 Oct 2011

Rasi Silvia, Bruscaggin Alessio, Rinaldi Andrea, Cresta Stefania, Fangazio Marco, De Paoli Lorenzo, Monti Sara, Gargiulo Ernesto, Kwee Ivo, Foà Robin, Bertoni Francesco, Gaidano Gianluca, Rossi Davide

Abstract excerpt

High-throughput genomics requires tumor DNA matched to germline DNA, that cannot be easily obtained in the context of leukemia. Using chronic lymphocytic leukemia as a model, saliva DNA was frequently devoid of tumor DNA also during overt disease, and passed quality controls for SNP-array (77/102, 75.4%) and next generation sequencing (71/102, 69.6%). Compared to saliva, urine provides germline DNA of similar...

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Identifiers

PMID: 21663967
DOI: 10.1016/j.leukres.2011.05.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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