Article
Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2011
Habermehl Daniel, Parkitna Jan Rodriguez, Kaden Sylvia, Brügger Britta, Wieland Felix, Gröne Hermann-Josef, Schütz Günther
Abstract excerpt
Corticosteroid treatment is an established therapy for preterm infants, and germline inactivation of the glucocorticoid receptor (GR) gene in the mouse leads to respiratory failure and postnatal lethality. Although glucocorticoids have been thought to critically act in epithelial cells inducing the functional maturation of the lung, inactivation of the GR gene exclusively in the epithelium of the developing...
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