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Article

Dexamethasone and sex regulate placental glucocorticoid receptor isoforms in mice

11 May 2017

Abstract excerpt

Maternal dexamethasone exposure in the mouse impairs placental development and programs adult disease in a sexually dimorphic manner. Glucocorticoids bind to different glucocorticoid receptor (GR) isoforms to regulate gene transcription and cellular signaling. We hypothesized that sexually dimorphic placental responses to glucocorticoids are due to differences in GR isoforms present in the placenta. Pregnant...

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PMID: 28490442
DOI: 10.1530/joe-17-0171

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