Article
Transgenic glucocorticoid receptor expression driven by the SP-C promoter reduces neonatal lung cellularity and midkine expression in GRhypo mice.
Biology of the neonate - 1 Jan 2006
Gagnon Stéphane, Atmodjo Wayhuni, Humes Daryl, McKerlie Colin, Kaplan Feige, Sweezey Neil B
Abstract excerpt
BACKGROUND: Congenital truncation of the glucocorticoid receptor (GR) is known to lead to lethal lung immaturity in newborn mice associated with increased lung cellularity (ratio of tissue to airspace) and, as we previously showed, prolonged expression of the retinoid-responsive growth factor midkine. OBJECTIVES: We sought to determine if these changes would be reversed by transgenic expression of GR exclusively...
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