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Article

arouser reveals a role for synapse number in the regulation of ethanol sensitivity.

Neuron - 9 Jun 2011

Eddison Mark, Guarnieri Douglas J, Cheng Ling, Liu Che-Hsiung, Moffat Kevin G, Davis Graeme, Heberlein Ulrike

Abstract excerpt

A reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol sedation mutants in Drosophila identified arouser (aru), which functions in developing neurons to reduce ethanol sensitivity. Genetic evidence suggests that aru regulates ethanol sensitivity through its activation by Egfr/Erk signaling and its inhibition by...

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Identifiers

PMID: 21658589
DOI: 10.1016/j.neuron.2011.03.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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