Article
Thymidine kinase gene transfer by herpes simplex virus.
Bulletin du cancer - 1 Jan 2000
Kraiselburd E
Abstract excerpt
The current state of knowledge concerning the biochemical transformation by Herpes Simplex virus (HSV) of mammalian cells lacking the enzyme thymidine kinase (TK) is reviewed. Transformation of thymidine kinase negative mouse cells (LTK-) to the TK+ phenotype by ultraviolet light-inactivated HSV preparations depends both on the irradiation dose and on the multiplicity of infection. Once stably associated with the...
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