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Article

An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation.

Genes and immunity - 1 Oct 2011

Finsterbusch M, Khare V, Campregher C, Evstatiev R, Gasche C

Abstract excerpt

Within the interleukin-10 receptor 1 (IL10R1) gene, two common variants are associated with certain diseases: single-nucleotide polymorphism 3 (SNP3), a serine-138 to glycine mutation is in linkage disequilibrium with SNP4, a glycine-330 to arginine mutation, both of which are considered loss-of-function alleles. However, the molecular consequence of G330R is unknown. We investigated possible roles of G330R on...

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Source

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Identifiers

PMID: 21654841
DOI: 10.1038/gene.2011.12
PMCID: PMC3173877

Genes

STAT3
JAK1
STAT1

Variants

Provenance

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