Article
Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth.
PloS one - 1 Jan 2019
Guo Qianqian, Ng Pei Qin, Shi Shanshan, Fan Diwen, Li Jun, Zhao Jing, Wang Hua, David Rakesh, Mittal Parul, Do Trung, Bock Ralph, Zhao Ming, Zhou Wenbin, Searle Iain
Abstract excerpt
Modified nucleosides in tRNAs are critical for protein translation. N1-methylguanosine-37 and N1-methylinosine-37 in tRNAs, both located at the 3'-adjacent to the anticodon, are formed by Trm5. Here we describe Arabidopsis thaliana AtTRM5 (At3g56120) as a Trm5 ortholog. Attrm5 mutant plants have overall slower growth as observed by slower leaf initiation rate, delayed flowering and reduced primary root length. In...
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