Article
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development.
Current biology : CB - 26 Aug 1999
Zhadanov A B, Provance D W, Speer C A, Coffin J D, Goss D, Blixt J A, Reichert C M, Mercer J A
Abstract excerpt
BACKGROUND: The establishment, maintenance and rearrangement of junctions between epithelial cells are extremely important in many developmental, physiological and pathological processes. AF-6 is a putative Ras effector; it is also a component of tight and adherens junctions, and has been shown to bind both Ras and the tight-junction protein ZO-1. In the mouse, AF-6 is encoded by the Af6 gene. As cell-cell...
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