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Article

Associations of polymorphisms in DNA repair genes and MDR1 gene with chemotherapy response and survival of non-small cell lung cancer.

PloS one - 1 Jan 2014

Du Yan, Su Tong, Zhao Lijun, Tan Xiaojie, Chang Wenjun, Zhang Hongwei, Cao Guangwen

Abstract excerpt

OBJECTIVES: We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum group D (XPD/ERCC2) rs13181, X-ray repair cross complementing group 1 (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene 1 (BRCA1) rs1799966 from the DNA repair pathway and multiple drug resistance 1 (MDR1/ABCB1) with...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Carcinoma, Non-Small-Cell Lung
Share to Demography
Share to DNA Repair
Share to Endonucleases
Share to Lung Neoplasms
Share to Neoplasm Staging
Share to Survival Analysis

Source

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Identifiers

PMID: 24933103
DOI: 10.1371/journal.pone.0099843
PMCID: PMC4059653

Genes

BRCA1
ABCB1
ERCC1
ERCC2
XRCC1
XRCC3

Provenance

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