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Article

Distal end of carboxyl terminus is not essential for the assembly of rat Eag1 potassium channels.

The Journal of biological chemistry - 5 Aug 2011

Chen I-Hsiu, Hu Jui-Hsiang, Jow Guey-Mei, Chuang Chao-Chin, Lee Ting-Ting, Liu Dai-Chi, Jeng Chung-Jiuan

Abstract excerpt

The assembly of four pore-forming α-subunits into tetramers is a prerequisite for the formation of functional K(+) channels. A short carboxyl assembly domain (CAD) in the distal end of the cytoplasmic carboxyl terminus has been implicated in the assembly of Eag α-subunits, a subfamily of the ether-à-go-go K(+) channel family. The precise role of CAD in the formation of Eag tetrameric channels, however, remains...

Topics

Animals
Cell Line
DNA, Complementary
Ether-A-Go-Go Potassium Channels
Fluorescent Antibody Technique
Glycosylation
Humans
Mutation
Patch-Clamp Techniques
Rats
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21646358
DOI: 10.1074/jbc.M111.233825
PMCID: PMC3149312

Genes

CAD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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