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Article

Transdominant inhibition of herpes simplex virus growth in transgenic mice.

Virology - 1 Dec 1992

Smith C A, DeLuca N A

Abstract excerpt

A mutant allele (X25) of an essential regulatory protein, ICP4, encoded by herpes simplex virus (HSV) has been shown to have a transdominant, negative effect on the activity of the wild-type protein, resulting in the inhibition of virus growth in vitro. The X25 protein appears to exert its transdominant effect by sequestering functional ICP4 monomers into nonfunctional, heterodimeric complexes (A. Shepard, P....

Topics

Alleles
Animals
Cells, Cultured
DNA-Binding Proteins
Fibroblasts
Gene Expression Regulation, Viral
Genes, Dominant
Immediate-Early Proteins
Immunity, Innate
Mice
Mice, Transgenic
Simplexvirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Viral Regulatory and Accessory Proteins

Virulence

Source

Identifiers

PMID: 1333114
DOI: 10.1016/0042-6822(92)90233-f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1333114-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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