Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments.

Nature cell biology - 5 Jun 2011

Hao Limin, Thein Melanie, Brust-Mascher Ingrid, Civelekoglu-Scholey Gul, Lu Yun, Acar Seyda, Prevo Bram, Shaham Shai, Scholey Jonathan M

Abstract excerpt

Sensory cilia are assembled and maintained by kinesin-2-dependent intraflagellar transport (IFT). We investigated whether two Caenorhabditis elegans α- and β-tubulin isotypes, identified through mutants that lack their cilium distal segments, are delivered to their assembly sites by IFT. Mutations in conserved residues in both tubulins destabilize distal singlet microtubules. One isotype, TBB-4, assembles into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tubulin
Share to Sensation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flagella

Share to Fluorescence Recovery After Photobleaching

Share to Mechanotransduction, Cellular

Share to Microtubule-Associated Proteins

Share to Microtubules

Source

Open in PubMed Open full text

Identifiers

PMID: 21642982
DOI: 10.1038/ncb2268
PMCID: PMC3129367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments.PMID 21642982Read ↗

Cell-specific α-tubulin TBA-6 and pan-ciliary IFT cargo RAB-28 generate a non-canonical transition zoneSemantic proximity Read ↗

Analysis of intraflagellar transport in C. elegans sensory cilia.Semantic proximity Read ↗

Measuring rates of intraflagellar transport along Caenorhabditis elegans sensory cilia using fluorescence microscopy.Semantic proximity Read ↗

Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.Semantic proximity Read ↗

Intraflagellar transport motors in Caenorhabditis elegans neurons.Semantic proximity Read ↗

The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.Semantic proximity Read ↗

The Role of Intraflagellar Transport in the Photoreceptor Sensory Cilium.Semantic proximity Read ↗

Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia.Semantic proximity Read ↗

The BBSome controls IFT assembly and turnaround in cilia.Semantic proximity Read ↗

Functional coordination of intraflagellar transport motors.Semantic proximity Read ↗

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin.Semantic proximity Read ↗

Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.