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Article

Blocking phosphatidylglycerol degradation in yeast defective in cardiolipin remodeling results in a new model of the Barth syndrome cellular phenotype.

The Journal of biological chemistry - 1 Jan 2022

Káňovičová Paulína, Čermáková Petra, Kubalová Dominika, Bábelová Lenka, Veselá Petra, Valachovič Martin, Zahumenský Jakub, Horváth Anton, Malínský Jan, Balážová Mária

Abstract excerpt

Barth syndrome (BTHS) is an inherited mitochondrial disorder characterized by a decrease in total cardiolipin and the accumulation of its precursor monolysocardiolipin due to the loss of the transacylase enzyme tafazzin. However, the molecular basis of BTHS pathology is still not well understood. Here we characterize the double mutant pgc1Δtaz1Δ of Saccharomyces cerevisiae deficient in...

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Identifiers

PMID: 34864056
DOI: 10.1016/j.jbc.2021.101462
PMCID: PMC8728584

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