Skp2 regulates Myc protein stability and activity.

doi:10.1016/s1097-2765(03)00173-4

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Article

Skp2 regulates Myc protein stability and activity.

Molecular cell - 1 May 2003

Kim So Young, Herbst Andreas, Tworkowski Kathryn A, Salghetti Simone E, Tansey William P

Abstract excerpt

Myc is an oncoprotein transcription factor that plays a prominent role in cancer. Like many transcription factors, Myc is an unstable protein that is destroyed by ubiquitin (Ub)-mediated proteolysis. Here, we report that the oncoprotein and Ub ligase Skp2 regulates Myc ubiquitylation and stability. Because of the growing number of Ub ligases that function as transcriptional coactivators, we speculated that Skp2...

Topics

Animals
Cell Cycle Proteins
Cell Line
Cell Transformation, Neoplastic
Eukaryotic Cells
Gene Expression Regulation, Neoplastic
Humans
Mutation
Neoplasms
Proto-Oncogene Proteins c-myc
S Phase
S-Phase Kinase-Associated Proteins
Transcriptional Activation
Ubiquitin
Yeasts

Source

Open in PubMed

Identifiers

PMID: 12769843
DOI: 10.1016/s1097-2765(03)00173-4

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