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Article

A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions

24 Oct 2000

Abstract excerpt

Glutamine/asparagine (Q/N)-rich domains have a high propensity to form self-propagating amyloid fibrils. This phenomenon underlies both prion-based inheritance in yeast and aggregation of a number of proteins involved in human neurodegenerative diseases. To examine the prevalence of this phenomenon, complete proteomic sequences of 31 organisms and several incomplete proteomic sequences were examined for Q/N-rich...

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PMID: 11050225
DOI: 10.1073/pnas.97.22.11910

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