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Article

Molecular evolution of the EGF-CFC protein family.

Gene - 15 Aug 2011

Ravisankar V, Singh Taran P, Manoj Narayanan

Abstract excerpt

The epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF-CFC) proteins, characterized by the highly conserved EGF and CFC domains, are extracellular membrane associated growth factor-like glycoproteins. These proteins are essential components of the Nodal signaling pathway during early vertebrate embryogenesis. Homologs of the EGF-CFC family have also been implicated in tumorigenesis in humans. Yet, little is...

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Identifiers

PMID: 21640172
DOI: 10.1016/j.gene.2011.05.007

Genes

EGF

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