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Article

Protein evolution: structure-function relationships of the oncogene beta-catenin in the evolution of multicellular animals.

Journal of experimental zoology. Part B, Molecular and developmental evolution - 15 Feb 2003

Schneider Stephan Q, Finnerty John R, Martindale Mark Q

Abstract excerpt

Beta-catenin functions as a cytoskeletal linker protein in cadherin-mediated adhesion and as a signal mediator in wnt-signal transduction pathways. We use a novel integrative approach, combining evolutionary, genomic, and three-dimensional structural data to analyze and trace the structural and functional evolution of beta-catenin genes. This approach also enabled us to examine the effects of gene duplication on...

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Identifiers

PMID: 12548541
DOI: 10.1002/jez.b.6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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