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A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.

Molecular biology and evolution - 3 Feb 2023

Truchado-García Marta, Perry Kimberly J, Cavodeassi Florencia, Kenny Nathan J, Henry Jonathan Q, Grande Cristina

Abstract excerpt

Asymmetries are essential for proper organization and function of organ systems. Genetic studies in bilaterians have shown signaling through the Nodal/Smad2 pathway plays a key, conserved role in the establishment of body asymmetries. Although the main molecular players in the network for the establishment of left-right asymmetry (LRA) have been deeply described in deuterostomes, little is known about the...

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PMID: 36537201
DOI: 10.1093/molbev/msac270
PMCID: PMC9907556

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