Article
The effect of urine pH on debrisoquine phenotyping: application of an HPLC-method.
International journal of clinical pharmacology, therapy, and toxicology - 1 May 1990
Kallio J
Abstract excerpt
The effect of urine pH on debrisoquine metabolic ratio (MR) was studied in 6 healthy volunteers. They were phenotyped on two separate occasions, firstly when urine was made alkaline with orally given sodium bicarbonate, and secondly when urine was acidified with oral ammonium chloride. The concen...
Topics
- Administration, Oral
- Adult
- Ammonium Chloride
- Bicarbonates
- Chromatography, High Pressure Liquid
- Debrisoquin
- Female
- Humans
- Hydrogen-Ion Concentration
- Isoquinolines
- Male
- Phenotype
- Sodium
- Sodium Bicarbonate
- Time Factors