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Article

The effect of urine pH on debrisoquine phenotyping: application of an HPLC-method.

International journal of clinical pharmacology, therapy, and toxicology - 1 May 1990

Kallio J

Abstract excerpt

The effect of urine pH on debrisoquine metabolic ratio (MR) was studied in 6 healthy volunteers. They were phenotyped on two separate occasions, firstly when urine was made alkaline with orally given sodium bicarbonate, and secondly when urine was acidified with oral ammonium chloride. The concentrations of debrisoquine and 4-hydroxydebrisoquine were analyzed by an HPLC (high performance liquid chromatographic)...

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PMID: 2163994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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