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Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells

18 Jun 1990

Abstract excerpt

We have isolated and sequenced 3 human DNA topoisomerase II (topo II) partial cDNA clones from a HeLa carcinoma cell cDNA library. Two clones were identical to an internal fragment of HeLa topo II cDNA. The third clone, CAA5, had a different and novel sequence which shared significant nucleotide (62%) and predicted peptide (70%) homologies with a region of the HeLa topo II cDNA. Our results suggest that HeLa...

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PMID: 2163884
DOI: 10.1016/0014-5793(90)81520-x

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