Article
Defective DNA topoisomerase II in ataxia-telangiectasia cells.
Acta biologica Hungarica - 1 Jan 1990
Lavin M F, Singh S P
Abstract excerpt
A number of characteristics in the human genetic disorder ataxia-telangiectasia are compatible with an alteration to chromatin structure or the recognition of that structure by an enzyme or DNA binding protein. We describe here reduce activity of DNA topoisomerase type II in a number of Epstein Barr Virus-transformed ataxia-telangiectasia lymphoblastoid cell lines. Enzyme activity was reduced 10-fold or greater...
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