Defective DNA topoisomerase II in ataxia-telangiectasia cells.

Article

Defective DNA topoisomerase II in ataxia-telangiectasia cells.

Acta biologica Hungarica - 1 Jan 1990

Lavin M F, Singh S P

Abstract excerpt

A number of characteristics in the human genetic disorder ataxia-telangiectasia are compatible with an alteration to chromatin structure or the recognition of that structure by an enzyme or DNA binding protein. We describe here reduce activity of DNA topoisomerase type II in a number of Epstein B...

Topics

Ataxia Telangiectasia
Cell Line
DNA Replication
DNA Topoisomerases, Type II
Humans
Mutation
RNA, Messenger

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