Genetic variations of orosomucoid genes associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.

doi:10.1002/jps.22648

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Article

Genetic variations of orosomucoid genes associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.

Journal of pharmaceutical sciences - 1 Oct 2011

Katori Noriko, Sai Kimie, Saito Yoshiro, Fukushima-Uesaka Hiromi, Kurose Kouichi, Yomota Chikako, Kawanishi Toru, Nishimaki-Mogami Tomoko, Naito Mikihiko, Sawada Jun-Ichi, Kunitoh Hideo, Nokihara Hiroshi, Sekine Ikuo, Ohe Yuichiro, Yoshida Teruhiko, Matsumura Yasuhiro, Saijo Nagahiro, Yamamoto Noboru, Okuda Haruhiro, Tamura Tomohide

Abstract excerpt

Alpha-1-acid glycoprotein (AGP) encoded by orosomucoid genes (ORM1 and ORM2) is an acute-phase response protein and functions as a drug-binding protein that affects pharmacokinetics (PK)/pharmacodynamics of binding drugs. To explore the effects of genetic variations of ORMs and a role of AGP on paclitaxel (PTX) therapy, we analyzed the duplication and genetic variations/haplotypes of ORMs in 165 Japanese cancer...

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PMID: 21638284
DOI: 10.1002/jps.22648

Genes

ORM1
ORM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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