Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphic transporters and platinum pharmacodynamics.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Sprowl Jason A, Ness Rachel A, Sparreboom Alex

Abstract excerpt

Several solute carriers and ATP-binding cassette transporters have been implicated in the influx or efflux of platinum-based chemotherapeutic agents such as cisplatin, carboplatin, and oxaliplatin. Given that many of these proteins are highly polymorphic, the genetic status of these proteins could be an important contributor to the extensive interindividual pharmacokinetic variability associated with the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cation Transport Proteins
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Multidrug Resistance-Associated Proteins

Share to Organic Cation Transport Proteins

Share to Platinum Compounds

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22986709
DOI: 10.2133/dmpk.dmpk-12-rv-073
PMCID: PMC3705946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphic transporters and platinum pharmacodynamics.PMID 22986709Read ↗

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.Semantic proximity Read ↗

Pharmacogenetics of membrane transporters: a review of current approaches.Semantic proximity Read ↗

Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapySemantic proximity Read ↗

Disease‐Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter ConsortiumSemantic proximity Read ↗

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy.Semantic proximity Read ↗

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.Semantic proximity Read ↗

Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC PerspectiveSemantic proximity Read ↗

Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy.Semantic proximity Read ↗

Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs.Semantic proximity Read ↗

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapySemantic proximity Read ↗

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.