Article
Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.
BMC cancer - 4 Jan 2011
Nakanishi Yutaka, Shiraha Hidenori, Nishina Shin-ichi, Tanaka Shigetomi, Matsubara Minoru, Horiguchi Shigeru, Iwamuro Masaya, Takaoka Nobuyuki, Uemura Masayuki, Kuwaki Kenji, Hagihara Hiroaki, Toshimori Junichi, Ohnishi Hideki, Takaki Akinobu, Nakamura Shinichiro, Kobayashi Yoshiyuki, Nouso Kazuhiro, Yagi Takahito, Yamamoto Kazuhide
Abstract excerpt
BACKGROUND: Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC). METHODS: RUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC cells and tissues, respectively. Hep3B cells, lacking endogenous RUNX3, were introduced with RUNX3 constructs. Cell...
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