Article
Knockdown of CENH3 in Arabidopsis reduces mitotic divisions and causes sterility by disturbed meiotic chromosome segregation.
The Plant journal : for cell and molecular biology - 1 Oct 2011
Lermontova Inna, Koroleva Olga, Rutten Twan, Fuchs Joerg, Schubert Veit, Moraes Izabel, Koszegi David, Schubert Ingo
Abstract excerpt
The histone H3 variant (CENH3) of centromeric nucleosomes is essential for kinetochore assembly and thus for chromosome segregation in eukaryotes. The mechanism(s) that determine centromere identity, assembly and maintenance of kinetochores are still poorly understood. Although the role of CENH3 during mitosis has been studied in several organisms, little is known about its meiotic function. We show that...
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