Article
Point mutation impairs centromeric CENH3 loading and induces haploid plants.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2015
Karimi-Ashtiyani Raheleh, Ishii Takayoshi, Niessen Markus, Stein Nils, Heckmann Stefan, Gurushidze Maia, Banaei-Moghaddam Ali Mohammad, Fuchs Jörg, Schubert Veit, Koch Kerstin, Weiss Oda, Demidov Dmitri, Schmidt Klaus, Kumlehn Jochen, Houben Andreas
Abstract excerpt
The chromosomal position of the centromere-specific histone H3 variant CENH3 (also called "CENP-A") is the assembly site for the kinetochore complex of active centromeres. Any error in transcription, translation, modification, or incorporation can affect the ability to assemble intact CENH3 chromatin and can cause centromere inactivation [Allshire RC, Karpen GH (2008) Nat Rev Genet 9 (12):923-937]. Here we show...
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