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In Silico Methods for Chromosome Damage.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Baderna Diego, Van Overmeire Ilse, Lavado Giovanna J, Gadaleta Domenico, Mertens Birgit

Abstract excerpt

Due to the link with serious adverse health effects, genotoxicity is an important toxicological endpoint in each regulatory setting with respect to human health, including for pharmaceuticals. To this extent, a compound potential to induce gene mutations as well as chromosome damage needs to be addressed. For chromosome damage, i.e., the induction of structural or numerical chromosome aberrations, several in...

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PMID: 35188633
DOI: 10.1007/978-1-0716-1960-5_8

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