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RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication

3 Jun 2011

Abstract excerpt

Hantaan virus (HTNV) causes severe human disease. The HTNV genome consists of three ssRNA segments of negative polarity that are complexed with viral nucleocapsid (N) protein. How the human innate immune system detects HTNV is unclear. RNA helicase retinoic acid-inducible gene I (RIG-I) does not sense genomic HTNV RNA. So far it has not been analysed whether pathogen-associated molecular patterns generated during...

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PMID: 21632559
DOI: 10.1099/vir.0.032367-0

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