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Article

Hantaan Virus Triggers TLR3-Dependent Innate Immune Responses

20 Feb 2009

Abstract excerpt

Immediately after viral infection, innate responses including expression of IFN-alpha/beta and IFN-stimulated genes (ISGs) are elicited ubiquitously by recruitment of specific pathogen recognition receptors. The velocity to induce IFN-alpha/beta and ISGs in response to an infection is often decisive for virulence. Interestingly, in primary endothelial cells ISGs are induced later by hantaviruses pathogenic to...

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PMID: 19234180
DOI: 10.4049/jimmunol.0802893

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