IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.

doi:10.1111/j.1462-5822.2006.00841.x

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Article

IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.

Cellular microbiology - 1 Apr 2007

Opitz Bastian, Rejaibi Amira, Dauber Bianca, Eckhard Jamina, Vinzing Maya, Schmeck Bernd, Hippenstiel Stefan, Suttorp Norbert, Wolff Thorsten

Abstract excerpt

Influenza A virus causes epidemics of respiratory diseases in humans leading to thousands of death annually. One of its major virulence factors, the non-structural protein 1 (NS1), exhibits interferon-antagonistic properties. While epithelial cells of the respiratory tract are the primary targets of influenza virus, the virus-sensing mechanisms in these cells eventually leading to IFNbeta production are...

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PMID: 17140406
DOI: 10.1111/j.1462-5822.2006.00841.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.