Article
Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels.
Cellular oncology (Dordrecht, Netherlands) - 1 Oct 2011
Duijkers Floor A M, Gaal José, Meijerink Jules P P, Admiraal Pieter, Pieters Rob, de Krijger Ronald R, van Noesel Max M
Abstract excerpt
BACKGROUND: In pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic role for ALK inhibitors in NBL patients. We examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and response to ALK inhibition in a large panel of both...
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