Article
DNA repair and sequence context affect (1)O(2)-induced mutagenesis in bacteria.
Nucleic acids research - 1 Jul 2001
Agnez-Lima L F, Napolitano R L, Fuchs R P, Mascio P D, Muotri A R, Menck C F
Abstract excerpt
Electronic excited molecular oxygen (singlet oxygen, (1)O(2)) is known to damage DNA, yielding mutations. In this work, the mutagenicity induced by (1)O(2) in a defined sequence of DNA was investigated after replication in Escherichia coli mutants deficient for nucleotide and base excision DNA repair pathways. For this purpose a plasmid containing a (1)O(2)-damaged 14 base oligonucleotide was introduced into...
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