Article
Dre - Cre sequential recombination provides new tools for retinal ganglion cell labeling and manipulation in mice.
PloS one - 1 Jan 2014
Sajgo Szilard, Ghinia Miruna Georgiana, Shi Melody, Liu Pinghu, Dong Lijin, Parmhans Nadia, Popescu Octavian, Badea Tudor Constantin
Abstract excerpt
BACKGROUND: Genetic targeting methods have greatly advanced our understanding of many of the 20 Retinal Ganglion Cell (RGC) types conveying visual information from the eyes to the brain. However, the complexity and partial overlap of gene expression patterns in RGCs call for genetic intersectional or sparse labeling strategies. Loci carrying the Cre recombinase in conjunction with conditional knock-out, reporter...
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