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Article

Mitochondria and Programmed Cell Death in Parkinson's Disease: Apoptosis and Beyond

28 May 2011

Abstract excerpt

UNLABELLED: Abstract Significance: Activation of mitochondrion-dependent programmed cell death (PCD) pathways is instrumental to the demise of substantia nigra pars compacta dopaminergic neurons in experimental mouse models of Parkinson's disease (PD). Supporting the relevance of these findings for PD, key molecular elements of this pathogenic cascade have also been demonstrated in postmortem brain samples of PD...

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Share to Cell death mechanisms and regulation
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Identifiers

PMID: 21619488
DOI: 10.1089/ars.2011.4074

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