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Article

Programmed Cell Death in Amyotrophic Lateral Sclerosis: a Mechanism of Pathogenic and Therapeutic Importance

1 Jan 2004

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disease of adulthood. Mounting evidence indicates that molecular components of the programmed cell death (PCD) machinery are implicated in the demise of motor neurons in this illness. PCD, rather than being passive, is an active mechanism of cell death tightly regulated by multiple molecular pathways. REVIEW SUMMARY: Thus far, little is known...

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PMID: 14720310
DOI: 10.1097/01.nrl.0000106920.84668.37

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