Death in the substantia nigra: a motor tragedy

Abstract excerpt

It is well known that the death of dopaminergic neurons of the substantia nigra pars compacta (SNc) is the pathological hallmark of Parkinson's disease (PD), the second most common and disabling condition in the expanding elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is largely symptomatic rather than preventive....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nerve injury and regeneration
• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments