Article

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

2019-02-05

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine release in the striatum. Accumulating evidence suggest that degeneration of axons is an early event in the disease, involving destruction programs that are independent of the survival of the ce...

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Literature Corpus work: 6ac893fe-f4cf-5dbe-a157-1a27d5918771
DOI: 10.1101/539700

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