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Article

Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

Journal of virology - 1 May 1991

Wong S W, Schaffer P A

Abstract excerpt

Like other DNA-containing viruses, the three origins of herpes simplex virus type 1 (HSV-1) DNA replication are flanked by sequences containing transcriptional regulatory elements. In a transient plasmid replication assay, deletion of sequences comprising the transcriptional regulatory elements of ICP4 and ICP22/47, which flank oriS, resulted in a greater than 80-fold decrease in origin function compared with a...

Topics

Animals
Base Sequence
Binding, Competitive
Cloning, Molecular
DNA Replication
DNA, Viral
Molecular Sequence Data
Mutation
Plasmids
Regulatory Sequences, Nucleic Acid
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Trans-Activators

Transcription, Genetic

Transfection

Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 1850034
DOI: 10.1128/JVI.65.5.2601-2611.1991
PMCID: PMC240618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850034-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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