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Article

Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

Journal of virology - 1 May 1991

Wong S W, Schaffer P A

Abstract excerpt

Like other DNA-containing viruses, the three origins of herpes simplex virus type 1 (HSV-1) DNA replication are flanked by sequences containing transcriptional regulatory elements. In a transient plasmid replication assay, deletion of sequences comprising the transcriptional regulatory elements of ICP4 and ICP22/47, which flank oriS, resulted in a greater than 80-fold decrease in origin function compared with a...

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Identifiers

PMID: 1850034
DOI: 10.1128/JVI.65.5.2601-2611.1991
PMCID: PMC240618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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