Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic Inactivation of the Dioxin-Responsive <i>Cytochrome P4501A1</i> Gene in Human Prostate Cancer

1 Aug 2006

Abstract excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD; dioxin) is a toxic environmental contaminant that works through dioxin response elements (DRE) to activate gene expression. We tested the hypothesis that cancer-related epigenetic changes suppress dioxin activation of the cytochrome P4501A1 (CYP1A1) gene. 5-Aza-2'-deoxycytidine (5-aza-CdR), an inhibitor of DNA methylation, increases TCDD-inducible CYP1A1 mRNA expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Effects and risks of endocrine disrupting chemicals
Share to Epigenetics and DNA Methylation
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16885337
DOI: 10.1158/0008-5472.can-06-0504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Epigenetic Inactivation of the Dioxin-Responsive <i>Cytochrome P4501A1</i> Gene in Human Prostate CancerPMID 16885337Read ↗

GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells.Semantic proximity Read ↗

Organization and function of a dioxin-responsive enhancer.Semantic proximity Read ↗

<i>GSTP1</i> CpG island hypermethylation as a molecular biomarker for prostate cancerSemantic proximity Read ↗

Expression, Function of the Human Androgen-Responsive Gene AD11 in Prostate CancerSemantic proximity Read ↗

Epigenetic Determinants of CYP1A1 Induction by the Aryl Hydrocarbon Receptor Agonist 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)Semantic proximity Read ↗

Gestational exposure to the AhR agonist 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin induces BRCA‐1 promoter hypermethylation and reduces BRCA‐1 expression in mammary tissue of rat offspring: Preventive effects of resveratrolSemantic proximity Read ↗

The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.Semantic proximity Read ↗

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.Semantic proximity Read ↗

Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.