Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human piRNAs are under selection in Africans and repress transposable elements.

Molecular biology and evolution - 1 Nov 2011

Lukic Sergio, Chen Kevin

Abstract excerpt

Piwi-interacting RNAs (piRNAs) are a recently discovered class of 24- to 30-nt noncoding RNAs whose best-understood function is to repress transposable elements (TEs) in animal germ lines. In humans, TE-derived sequences comprise ∼45% of the genome and there are several active TE families, including LINE-1 and Alu elements, which are a significant source of de novo mutations and intrapopulation variability. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Black People
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetics, Population

Share to Pan troglodytes

Share to RNA, Small Interfering

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21613236
DOI: 10.1093/molbev/msr141
PMCID: PMC3199439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human piRNAs are under selection in Africans and repress transposable elements.PMID 21613236Read ↗

A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elementsSemantic proximity Read ↗

Human Alu elements promote the establishment and enhancement of piRNA-protein-coding gene targeting relationshipsSemantic proximity Read ↗

An ancient and still ongoing genetic conflict between transposable elements and their repressorsSemantic proximity Read ↗

Rapid repetitive element-mediated expansion of piRNA clusters in mammalian evolution.Semantic proximity Read ↗

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillanceSemantic proximity Read ↗

Integrated small and long RNA sequencing in single oocytes reveals piRNA-mediated transposon repression during human oogenesisSemantic proximity Read ↗

Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseasesSemantic proximity Read ↗

Estimating the retrotransposition rate of human Alu elements.Semantic proximity Read ↗

Alu repeat discovery and characterization within human genomes.Semantic proximity Read ↗

The PIWI/piRNA response is relaxed in a rodent that lacks mobilizing transposable elementsSemantic proximity Read ↗

piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammalsSemantic proximity Read ↗

Rapid evolution of piRNA-mediated silencing of an invading transposable element was driven by abundant de novo mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.