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Article

Reduced levels of ATF-2 predispose mice to mammary tumors.

Molecular and cellular biology - 1 Mar 2007

Maekawa Toshio, Shinagawa Toshie, Sano Yuji, Sakuma Takahiko, Nomura Shintaro, Nagasaki Koichi, Miki Yoshio, Saito-Ohara Fumiko, Inazawa Johji, Kohno Takashi, Yokota Jun, Ishii Shunsuke

Abstract excerpt

Transcription factor ATF-2 is a nuclear target of stress-activated protein kinases, such as p38, which are activated by various extracellular stresses, including UV light. Here, we show that ATF-2 plays a critical role in hypoxia- and high-cell-density-induced apoptosis and the development of mammary tumors. Compared to wild-type cells, Atf-2(-/-) mouse embryonic fibroblasts (MEFs) were more resistant to hypoxia-...

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Identifiers

PMID: 17189429
DOI: 10.1128/MCB.01579-06
PMCID: PMC1820478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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