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Article

Inhibition of eukaryotic translation initiation factor 1 A (eIF1A) and 3B (eIF3B) diminishes the psoriatic phenotype in two mouse models and human 3D model samples.

Journal of dermatological science - 1 May 2026

Golob-Schwarzl Nicole, Bordag Natalie, Shirsath Nitesh, Müller Christin-Therese, El-Heliebi Amin, Wolf Peter

Abstract excerpt

BACKGROUND: Psoriasis is a systemic inflammatory skin disease for which new topical treatments are needed. Psoriatic inflammation is associated with overexpression of eukaryotic translation initiation factors (eIFs), which regulate gene expression in processes such as proliferation, apoptosis, and differentiation. However, their role in psoriasis remains unclear. OBJECTIVE: To investigate the contribution of...

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PMID: 41916779
DOI: 10.1016/j.jdermsci.2026.03.008

Genes

FLG
KRT16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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