Article
The zebrafish gene claudinj is essential for normal ear function and important for the formation of the otoliths.
Mechanisms of development - 1 Jul 2005
Hardison Amanda L, Lichten Lauren, Banerjee-Basu Sharmila, Becker Thomas S, Burgess Shawn M
Abstract excerpt
We have identified a mutation in the zebrafish gene claudinj generated by retroviral integration. Mutant embryos display otoliths severely reduced in size, no response to tapping stimulus, and an inability to balance properly suggesting vestibular and hearing dysfunction. Antisense in situ hybridization to the cldnj gene showed expression first in the otic placode and later asymmetric expression in the otic...
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