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Article

Claudin7b is required for the formation and function of inner ear in zebrafish.

Journal of cellular physiology - 1 Apr 2018

Li Xiaohui, Song Guili, Zhao Yasong, Zhao Feng, Liu Chunyan, Liu Dong, Li Qing, Cui Zongbin

Abstract excerpt

Zebrafish has become an excellent model for studying the development and function of inner ear. We report here a zebrafish line in which claudin 7b (cldn7b) locus is interrupted by a Tol2 transposon at its first intron. The homozygous mutants have enlarged otocysts, smaller or no otoliths, slowly formed semicircular canals, and insensitiveness to sound stimulation. These abnormal phenotypes and hearing loss of...

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PMID: 28834538
DOI: 10.1002/jcp.26162

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