Article
Induction of leukemia in chicken by bovine leukemia virus due to insertional mutagenesis.
Archiv fur Geschwulstforschung - 1 Jan 1990
Altanerova V, Ban J, Kettmann R, Altaner C
Abstract excerpt
Bovine leukemia virus (BLV) was inoculated into one-day-old chickens. In a small part of inoculated chickens leukemia developed during observation period of one year. Out of 88 birds inoculated, only 4 developed histopathologically verified leukemia. The induced leukemia was characterized by enlarged liver and spleen. The organs were infiltrated with leukemic cells. The DNAs of body organs of inoculated chickens...
Topics
- Animals
- Blotting, Southern
- Chickens
- Leukemia Virus, Bovine
- Leukemia, Experimental
- Mutation
- Proto-Oncogenes
- Retroviridae
