Article
Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.
Alcoholism, clinical and experimental research - 1 Sept 2011
Lasek Amy W, Giorgetti Francesco, Berger Karen H, Tayor Stacy, Heberlein Ulrike
Abstract excerpt
BACKGROUND: Previous work from our laboratory demonstrated a role for the Drosophila Lim-only (dLmo) gene in regulating behavioral responses to cocaine. Herein, we examined whether dLmo influences the flies' sensitivity to ethanol's sedating effects. We also investigated whether 1 of the mammalian homologs of dLmo, Lmo3, is involved in behavioral responses to ethanol in mice. METHODS: To examine dLmo function in...
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