Genetic and molecular risk factors within the newly identified primate-specific exon of the SAP97/DLG1 gene in the 3q29 schizophrenia-associated locus.

doi:10.1002/ajmg.b.32595

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Article

Genetic and molecular risk factors within the newly identified primate-specific exon of the SAP97/DLG1 gene in the 3q29 schizophrenia-associated locus.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2017

Uezato Akihito, Yamamoto Naoki, Jitoku Daisuke, Haramo Emiko, Hiraaki Eri, Iwayama Yoshimi, Toyota Tomoko, Umino Masakazu, Umino Asami, Iwata Yasuhide, Suzuki Katsuaki, Kikuchi Mitsuru, Hashimoto Tasuku, Kanahara Nobuhisa, Kurumaji Akeo, Yoshikawa Takeo, Nishikawa Toru

Abstract excerpt

The synapse-associated protein 97/discs, large homolog 1 of Drosophila (DLG1) gene encodes synaptic scaffold PDZ proteins interacting with ionotropic glutamate receptors including the N-methyl-D-aspartate type glutamate receptor (NMDAR) that is presumed to be hypoactive in brains of patients with schizophrenia. The DLG1 gene resides in the chromosomal position 3q29, the microdeletion of which confers a 40-fold...

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PMID: 28990294
DOI: 10.1002/ajmg.b.32595

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DLG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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