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Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening

21 Oct 2020

Abstract excerpt

Cancer cell dormancy is a common feature of human tumors and represents a major clinical barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in primary tumors or disseminated in secondary organs, may reawaken and relapse into more aggressive disease. The mechanisms underpinning dormancy entry and exit strongly resemble those governing cancer cell stemness, and include intrinsic...

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PMID: 33193295
DOI: 10.3389/fimmu.2020.02166

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