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Mycobacteria Encode Active and Inactive Classes of TesB Fatty-Acyl CoA Thioesterases Revealed through Structural and Functional Analysis.

Biochemistry - 14 Mar 2017

Swarbrick Crystall M D, Bythrow Glennon V, Aragao David, Germain Gabrielle A, Quadri Luis E N, Forwood Jade K

Abstract excerpt

Mycobacteria contain a large number of highly divergent species and exhibit unusual lipid metabolism profiles, believed to play important roles in immune invasion. Thioesterases modulate lipid metabolism through the hydrolysis of activated fatty-acyl CoAs; multiple copies are present in mycobacteria, yet many remain uncharacterized. Here, we undertake a comprehensive structural and functional analysis of a TesB...

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Acyl Coenzyme A
Alanine
Aspartic Acid
Hydrolysis
Mycobacterium avium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium smegmatis

Protein Domains

Protein Structure, Quaternary

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PMID: 28156101
DOI: 10.1021/acs.biochem.6b01049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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